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2026, 02, v.43 8-14
壳聚糖及其衍生物在药物递送载体中的研究进展
基金项目(Foundation): 国家自然科学基金项目(32370987); 浙江省自然科学基金重点项目(LZ26C180002); 台州市重点科技计划项目(25gyz06); 台州市科技计划项目(24nya05,25nya05,25nya07,25nya17)
邮箱(Email): zybin395@126.com;
DOI:
摘要:

壳聚糖及其衍生物因低毒性、良好的生物相容性和抗菌等特性,常被应用于疫苗佐剂和药物载体等领域。利用壳聚糖及其衍生物构建新型药物递送系统,提高了药物的生物利用度,降低了药物的副作用,并增强了黏膜的黏附性。在介绍几种壳聚糖及其衍生物纳米粒的制备方法、原理及特性的基础上,分析了壳聚糖及其衍生物作为药物递送载体的优势,比较了壳聚糖基药物递送载体的给药方式,并对其发展前景进行了展望。

Abstract:

Chitosan and its derivatives are used in vaccine adjuvants and drug carriers due to their low toxicity, good biocompatibility, and antibacterial properties.The construction of a novel drug delivery system using chitosan and its derivatives has enhanced the bioavailability of drugs, reduced the side-effects of drugs, and strengthened the mucosal adhesion.In this paper, based on the introduction of preparation methods, principles, and characteristics of several chitosan and its derivatives nanoparticles, we analyze the advantages of chitosan and its derivatives as drug delivery carriers, compare the drug delivery modes of chitosan-based drug delivery system, and put forward the development prospects.

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基本信息:

中图分类号:O636.1;TQ460.4

引用信息:

[1]程尹弟,薛营,徐山根,等.壳聚糖及其衍生物在药物递送载体中的研究进展[J].化学与生物工程,2026,43(02):8-14.

基金信息:

国家自然科学基金项目(32370987); 浙江省自然科学基金重点项目(LZ26C180002); 台州市重点科技计划项目(25gyz06); 台州市科技计划项目(24nya05,25nya05,25nya07,25nya17)

发布时间:

2026-02-02

出版时间:

2026-02-02

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